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G4 DNA binding of EWS was reduced by adding an excess of the G4 RNA competitor and G4 RNA binding of EWS was reduced by adding an excess of the G4 DNA competitor

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For the determination of IC 50 values, cells were treated with the following conditions: fresh culture medium alone (control), fresh culture medium with compound 22 , 24 , 32 and 34 at concentrations ranging from 1 µM to 1000 µM for 24 h